Wu's Blog

The smartd service  can leads to ESXi 6.0 or 6.5 hosts no responding due to out of memory. I see that issue on ESXi 6.0 U2 and U3 both. I would recommend stay on  ESXi 5.5 U3 at this moment. We do see the issue persist even after stop smartd service. Check out VMware official KB .

Just noticed a gap here. If your  ESXi host is 5.5 Update 2 or earlier version, you are not able to choose 'Windows Server 2016' as operating system  when  you create virtual  machine. It's addressed in  KB https://kb.vmware.com/kb/2132789.