ESXi 6.0 and 6.5 hosts no responding issue!
The smartd service can leads to ESXi 6.0 or 6.5 hosts no responding due to out of memory. I see that issue on ESXi 6.0 U2 and U3 both. I would recommend stay on ESXi 5.5 U3 at this moment. We do see the issue persist even after stop smartd service. Check out VMware official KB .